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KMID : 1161420130160030255
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Journal of Medicinal Food
2013 Volume.16 No. 3 p.255 ~ p.258
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Red Grape Seed Extract Improves Lipid Profiles and Decreases Oxidized Low-Density Lipoprotein in Patients with Mild Hyperlipidemia
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Razavi Seyed-Mostafa
Gholamin Sharareh
Eskandari Ali
Mohsenian Nakta
Ghorbanihaghjo Amir
Delazar Abbas
Rashtchizadeh Nadereh
Keshtkar-Jahromi Maryam
Argani Hassan
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Abstract
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Hyperlipidemia can lead to atherosclerosis by lipoprotein deposition inside the vessel wall and oxidative stress induction that leads to the formation of atherosclerotic plaque. Oxidized low-density lipoprotein particles (Ox-LDL) have a key role in the pathogenesis of atherosclerosis. The lipid-lowering properties and antioxidants of the grape seed can be beneficial in atherosclerosis prevention. We conducted a randomized double-blind placebo-controlled crossover clinical trial. Fifty-two mildly hyperlipidemic individuals were divided into two groups that received either 200?mg/day of the red grape seed extract (RGSE) or placebo for 8 weeks. After an 8-week washout period, the groups were crossed over for another 8 weeks. Lipid profiles and Ox-LDL were measured at the beginning and the end of each phase. RGSE consumption reduced total cholesterol (?10.68±26.76?mg/dL, P=.015), LDL cholesterol (?9.66±23.92?mg/dL, P=.014), and Ox-LDL (?5.47±12.12?mg/dL, P=.008). While triglyceride and very low?density lipoprotein cholesterol were decreased and high-density lipoprotein cholesterol was increased by RGSE, the changes were not statistically significant. RGSE consumption decreases Ox-LDL and has beneficial effects on lipid profile?consequently decreasing the risk of atherosclerosis and cardiovascular disorders?in mild hyperlipidemic individuals.
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KEYWORD
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atherosclerosis, grape seed extract, lipid profile, oxidative stress
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